Neuromuscular Genetics

What are Neuromuscular Disorders?

Neuromuscular Disorders (NMD) are a group of conditions characterized by progressive muscle degeneration and weakness that most often have a genetic cause. Most of these genetic variants display autosomal recessive, autosomal dominant, or X-linked inheritance.

What are some Neuromuscular Disorders with Genetic Causes?

  • Spinal Muscular Atrophy

  • Duchenne Muscular Dystrophy (DMD)

  • Limb-Girdle Muscular Dystrophies (LGMD)

  • Spastic Paraplegia (SPG)

  • Motor Neuron Diseases (ex. ALS)

  • Any congenital muscular dystrophies and myopathies

Who can benefit from genetic counseling for Neuromuscular Disorders?

  • Individuals with a personal or family history of seizures, brain tumors, neurodegenerative diseases, or neuromuscular disorders

  • Individuals experiencing abnormal muscle weakness, fatigue, or pain

  • Individuals seeking guidance on their options for gene therapies for their current neurological or neuromuscular condition (including cancers of the nervous system)

How Can Clover Genetics Help?

  • Identify genetic testing, support, and care programs as needed

  • Facilitate the identification of treatments or clinical trials

  • Empower patients to identify and manage their care needs

  • Facilitate counseling for affected, or at risk family members